Perbandingan Hasil COVID-19 Metode Rapid Antigen Test dengan PCR: Literature Review

Siti Rachmawati, Yuanita Windusari, Hamzah Hasyim


The basis for the identification of SARS-CoV-2 cases in handling the COVID-19 pandemic is Reverse Transcriptasi Polymerase (RT-PCR) and the SARS-CoV-2 specific rapid antigen test. RT-PCR test takes a long time and expensive to get results, while the SARS-CoV-2 rapid antigen test is a simple and fast alternative in getting COVID-19 detection results. The method used is descriptive observational in the form of a literature review by reviewing the existing literature. Several screening and confirmatory tests are available to detect SARS-CoV-2. Screening tests such as the Rapid Antigen Test (RAT) can identify high-risk populations. RAT reduces dependence on RT-PCR, where the cost of the RT-PCR kit and technical expertise is a major concern. Precise and sensitive molecular technique that quantitatively detects viral RNA from clinical specimens. RAT for COVID-19 showed lower sensitivity than RT-PCR for both symptomatic (single or multiple symptoms) and asymptomatic infections.


Rapid Antigen Test; PCR; SARS-CoV-2

Full Text:



European Center for Disease Prevention and Control (ECDC). 2021. Options for the use of rapid antigen tests for COVID-19 in the EU/EEA and the UK. Technical Report. Available: Diakses 10 oktober 2021.

Ferte, T, Ramel, V, Cazanave, C, Lafon, M.E, Bebear, C, Malvy, D, Walryck, A.G, Dehail, P. 2021. Accuracy of COVID-19 rapid antigenic tests compared to RT-PCR in a student population: The StudyCov study. Journal of Clinical Virology. 141. Elsivier.

Krüttgen, A, Cornelissen, C.G, Dreher, M, Hornef , M.W, Imohl, M, Kleines, M. 2021. Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit. Journal of Virological Methods, 288. Elsevier.

Munne, K, Bhanothu V, Mayekar, A, Birje, S, Bhor, V, Patel, V, Mahale, S.D, Pande, S.S. 2001. A retrospective analysis of COVID-19 diagnosis results obtained by rapid antigen tests and RT-PCR: Implications for disease management. Indian Journal of Medical Microbiology. 39, 537–539. Elsevier.

Peña, M, Ampuero, M, Garcés, C, Gaggero, A, García, P, Velasquez, M.S, Luza, R, Alvarez, P, Paredes, F, Acevedo, J, Farfán, M.J, Solari, S, Rifo, R.S, Echeverría, F.V.2021. Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals. International Journal of Infectious Diseases 107, 201–204. Elsevier.

Prakash, P, Saurabh, K, Shahi, S.K, Kumari, N. 2021. To Study The Diagnostic Relevance Of Rapid Antigen Test For COVID-19 As Compared To Sars-Cov-2 Rt-Pcr With Special Reference To Rdrp Ct Value, Indian Journal of Medical Microbiology 39, S1–S133.

Rahman, M.M, Hoque, A.F, Karim, Y, Kawser, Z, Siddik, A.B, Sumiya, M.K, Siddika, A, Alam, M.S, Alam, A.N, Alam, M, Hossain, M.E, Banu, S, Qadri, F, Shirin, T, Rahman, M, Rahman, M.Z. 2021. Clinical evaluation of SARS-CoV-2 antigen-based rapid diagnostic test kit for detection of COVID-19 cases in Bangladesh. Heliyon, 7. Elsevier.

Thell, R, Kallab, V, Weinhappel, W, Mueckstein, W, Hesch, L, Hesch, M, Korsatko, S, Toedling, F, Blaschke, A, Herzog, T, Klicpera, A, Koeller, C, Haugk, M, Kreil, A, Spiel, A, Kreuzer, P, Krause, R, Sebesta, C, Winkler, S, Laky, B, Szell, M. 2021. Evaluation of a novel, rapid antigen detection test for the diagnosis of SARS-CoV-2. Plos One.

World Health Organization (WHO). 2021. Coronavirus disease (COVID-19) Pandemic–Emergency Use Listing Procedure (EUL) open for in vitro diagnostics. Geneva: WHO. Available: Diakses 10 oktober 2021.

Zhou, P, Yang, X.L, Wang, X.G, Hu, B, Zhang, L, Si, H.R, Zhu, Y, Huang, C.L, Chen, J, Luo, Y, Guo, H, Jiang, R.D, Liu, M.Q, Chen, Y, Shen, X.R, Wang, X, Zheng, X.S, Zhao, K, Chen, Q.J, Deng, F, Liu, L.L, Yang, B, Zhan, F.X, Wang, Y.Y, Xiao, G.F, Shi, Z,L. 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature volume 579, 270–273.



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


Published by Lembaga Penelitian dan Pengabdian kepada Masyarakat
Adress: Jl.Slamet Ryadi, Broni-Jambi, Kec.Telanaipura, Kodepos: 36122, email:, Phone: 0741-670700

Creative Commons License This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.